mutfunc Help Biology Diagrams In normal cells, PKD directly phosphorylates MFF on serines 155, 172, and 275 and promotes mitochondrial fission specifically during mitosis. These phosphorylation events do not take place in interphase cells and are independent of the previously reported AMPK-dependent signaling occurring under low energy stress conditions (Toyama et al., 2016
Mitosis is characterized by an ordered series of events in which first the nuclear envelope breaks down, chromosomes compact, and the mitotic spindle starts to assemble. kinases alone are insufficient to control dynamic processes such as mitosis because the phosphorylation of serine and threonine residues is extremely stable, with the half
Protein phosphatases in the regulation of mitosis Biology Diagrams
Nevertheless, a comprehensive and mechanistic knowledge of mitotic events controlled by tyrosine phosphorylation remains limited and the only PTPs with well-established essential roles in mitosis are the dual-specificity phosphatases, cell division cycle 14 (CDC14) and cell division cycle 25 (CDC25) [84,85,86]. Phosphatases of the CDC25 family The data reveal a massive wave of phosphorylation during mitosis, predominantly within the cyclin-dependent kinase target motif [pS/pT]-P, suggesting that most of the sites may be direct targets of CDKs. Among the regulated phosphorylation sites are many canonical cell cycle regulated events and many unreported sites on known cell cycle regulators.
Almost all eukaryotic proteins are subject to post-translational modifications during mitosis and cell cycle, and in particular, reversible phosphorylation being a key event. The recent use of high-throughput experimental analyses has revealed that
Protein Phosphatases Involved in Regulating Mitosis: Facts and ... Biology Diagrams
A burst in protein phosphorylation orchestrated by several conserved kinases occurs as cells go into and progress through mitosis. The opposing dephosphorylation events are catalyzed by a small set of protein phosphatases, whose importance for the accuracy of mitosis is becoming increasingly appreciated.
